Mabel Creek Station was once a sheep and cattle station. Mabel Creek traditionally supported 20,000-25,000 sheep, but significant woody weed infestations on the station had reduced carrying capacity. Cattle consisted of Hereford-Angus cross and Santa Gertrudis-Shorthorn cross as well as a permanently agisted cattle herd through to the mid 2010s however the property has now been destocked and is in neglect. The 5000 square kilometre station was bought by the Aboriginal and Torres Strait Islander Commission (ATSIC) in 1994 for the Tjaliri Aboriginal Group, and now operates as its own concern. There was once a plan for a Carbon Farm project to be run here.
Mabel Creek Station once housed the Tjaliri Tracking Station used in 1995 for the EXPRESS re-entry capsule mission, a collaborative program between Germany and Japan which involved the targeted landing of an unmanned re-entry capsule in the
Woomera Test Range. This tracking station provided a full tracking, telemetry and command capability and included an Intelsat earth station link to the control centre in Germany.